Department of Family Medicine, University of Michigan, 1500 E. Medical Center Drive, Room 2150 Cancer Center, Ann Arbor, MI, 48109-5930, USA. Department of Pathology and Karmanos Cancer Institute, Wayne State University, Detroit, MI, 48201, USA. Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109-5930, USA. Department of Statistics, University of Michigan, Ann Arbor, MI, 48109-5930, USA. Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109-5930, USA. Department of Family Medicine, University of Michigan, 1500 E. Medical Center Drive, Room 2150 Cancer Center, Ann Arbor, MI, 48109-5930, USA. zoralong@umich.edu.